For this product we require a completed Drug & Chemical Affidavit on file. If you have not submitted this form to us, please click here, and fax (813-671-8237) or email (fishsupplies@verizon.net) back to us. Thank You. AVAILABLE FOR REGISTERED DEALERS AND WHOLESALERS ONLY! USE: Gram-positive and gram-negative bacteria. Marine ulcer disease, cold water disease, bacterial hemmorrhagic septicemia and mouth fungus. DOSAGE: 1/4 teaspoon per 20 gallons every 24 hours with a 25% water change before each treatment. Treat for 10 days. 250 grams (treats 4000 gal.) Or, if mixed into feed, 2 teaspoons per pound of Koi pellets. Feed for 14 - 21 days. If your pH is 8.0 or above, it is suggested to use this medication in the feed.